Version 5.4
| Mus musculus Protein: Kcnq5 | |||||||||||
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| Summary | |||||||||||
| InnateDB Protein | IDBP-137295.6 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | Kcnq5 | ||||||||||
| Protein Name | potassium voltage-gated channel, subfamily Q, member 5 | ||||||||||
| Synonyms | |||||||||||
| Species | Mus musculus | ||||||||||
| Ensembl Protein | ENSMUSP00000029667 | ||||||||||
| InnateDB Gene | IDBG-137293 (Kcnq5) | ||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||
| Function | Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current (By similarity). {ECO:0000250}. | ||||||||||
| Subcellular Localization | Membrane; Multi-pass membrane protein. | ||||||||||
| Disease Associations | |||||||||||
| Tissue Specificity | |||||||||||
| Comments | |||||||||||
| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||
| PDB ID | MGI:1924937 | ||||||||||
| InterPro |
IPR003091
Potassium channel IPR003937 Potassium channel, voltage dependent, KCNQ IPR005821 Ion transport domain IPR013099 Two pore domain potassium channel domain IPR013821 Potassium channel, voltage dependent, KCNQ, C-terminal |
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| PFAM |
PF00520
PF07885 PF03520 |
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| PRINTS |
PR00169
PR01459 |
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| PIRSF | |||||||||||
| SMART | |||||||||||
| TIGRFAMs | |||||||||||
| Post-translational Modifications | |||||||||||
| Modification | |||||||||||
| Cross-References | |||||||||||
| SwissProt | Q9JK45 | ||||||||||
| PhosphoSite | PhosphoSite-Q9JK45 | ||||||||||
| TrEMBL | Q9CTU2 | ||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 226922 | ||||||||||
| UniGene | Mm.396950 | ||||||||||
| RefSeq | NP_076361 | ||||||||||
| MGI ID | |||||||||||
| MGI Symbol | Kcnq5 | ||||||||||
| OMIM | |||||||||||
| CCDS | CCDS35525 | ||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| EMBL | AF263836 AK020325 AK033079 AY679158 | ||||||||||
| GenPept | AAF73447 AAT76442 BAB32071 BAC28145 | ||||||||||