InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptpn12

Summary

InnateDB Protein

IDBP-137315.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptpn12

Protein Name

protein tyrosine phosphatase, non-receptor type 12

Synonyms

P19-PTP; PTP-P19; PTP-PEST; PTPG1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030556

InnateDB Gene

IDBG-137313 (Ptpn12)

Protein Structure

UniProt Annotation

Function

Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12674328}. Cell projection, podosome {ECO:0000269PubMed:12674328}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	43 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity
GO:0017124	SH3 domain binding

Biological Process

GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0042246	tissue regeneration

Cellular Component

GO:0002102	podosome
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0030054	cell junction
GO:0042995	cell projection

Protein Structure and Domains

PDB ID

MGI:104673

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR012266 Protein-tyrosine phosphatase, non-receptor type-12
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102

PRINTS

PR00700

PIRSF

PIRSF000932

SMART

SM00194
SM00404

TIGRFAMs

Post-translational Modifications

Modification

Cross-References