InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ptpn12

Summary

InnateDB Gene

IDBG-137313.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptpn12

Gene Name

protein tyrosine phosphatase, non-receptor type 12

Synonyms

P19-PTP; PTP-P19; PTP-PEST; PTPG1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028771

Encoded Proteins

IDBP-137315

protein tyrosine phosphatase, non-receptor type 12

IDBP-540476

protein tyrosine phosphatase, non-receptor type 12

IDBP-534661

protein tyrosine phosphatase, non-receptor type 12

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000127947:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:20986645-21055911

Strand

Reverse strand

Band

Transcripts

ENSMUST00000030556	ENSMUSP00000030556
ENSMUST00000151366
ENSMUST00000148711
ENSMUST00000126853
ENSMUST00000151813	ENSMUSP00000116989
ENSMUST00000140057	ENSMUSP00000117697

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	43 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity
GO:0017124	SH3 domain binding

Biological Process

GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0042246	tissue regeneration

Cellular Component

GO:0002102	podosome
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0030054	cell junction
GO:0042995	cell projection

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000127947

View Gene Order

ENSBTAG00000003825

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_4

EGFR1 pathway

NetPath_11

TCR pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.319117

RefSeq

NM_011203 XM_006535640 XM_006535641 XM_006535642 XM_006535643

OMIM

CCDS

CCDS19102

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas