InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zfpm2

Summary

InnateDB Protein

IDBP-137410.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zfpm2

Protein Name

zinc finger protein, multitype 2

Synonyms

B330005D23Rik; FOG-2; FOG2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000051335

InnateDB Gene

IDBG-137408 (Zfpm2)

Protein Structure

UniProt Annotation

Function

Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2. {ECO:0000269PubMed:10330188, ECO:0000269PubMed:10888889, ECO:0000269PubMed:10892744, ECO:0000269PubMed:12223418, ECO:0000269PubMed:9927674, ECO:0000269PubMed:9927675}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:10330188, ECO:0000269PubMed:9927674, ECO:0000269PubMed:9927675}.

Disease Associations

Tissue Specificity

Expressed in heart, brain and testis. Weakly expressed in lung and liver. First expressed at approximately E8.5 in the developing ventral heart tube and septum transversum. Cardiac expression persists throughout the remainder of embryonic development in the atria as well as in all layers of the ventricles (endocardium, myocardium, and pericardium). Expressed in the neuroepithelium of the developing midbrain and hindbrain from E11.5 and increased in intensity between E12 and E16.5. Also expressed in the urogenital ridge beginning at E11.5 and subsequently localized to the gonads by E16.5. Colocalizes with GATA4 GATA5 and GATA6 in the developing heart, GATA3 in the brain, and GATA4 in the gonads. {ECO:0000269PubMed:10330188, ECO:0000269PubMed:9927674, ECO:0000269PubMed:9927675}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001071	nucleic acid binding transcription factor activity
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001570	vasculogenesis
GO:0001701	in utero embryonic development
GO:0003148	outflow tract septum morphogenesis
GO:0003151	outflow tract morphogenesis
GO:0003181	atrioventricular valve morphogenesis
GO:0003192	mitral valve formation
GO:0003195	tricuspid valve formation
GO:0003221	right ventricular cardiac muscle tissue morphogenesis
GO:0006351	transcription, DNA-templated
GO:0007507	heart development
GO:0030324	lung development
GO:0045087	innate immune response (InnateDB)
GO:0045599	negative regulation of fat cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048568	embryonic organ development
GO:0048738	cardiac muscle tissue development
GO:0055008	cardiac muscle tissue morphogenesis
GO:0060412	ventricular septum morphogenesis
GO:0060548	negative regulation of cell death
GO:0060979	vasculogenesis involved in coronary vascular morphogenesis
GO:2000020	positive regulation of male gonad development
GO:2000195	negative regulation of female gonad development