Version 5.4
Mus musculus Gene: Zfpm2
Summary
InnateDB Gene IDBG-137408.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Zfpm2
Gene Name zinc finger protein, multitype 2
Synonyms B330005D23Rik; FOG-2; FOG2
Species Mus musculus
Ensembl Gene ENSMUSG00000022306
Encoded Proteins
IDBP-137410
zinc finger protein, multitype 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21971825
Zfpm2 inhibits the transcription of hepcidin antimicrobial peptide by suppressing the GATA4 and GATA6 transcription factors. (Demonstrated in human)
InnateDB Annotation from Orthologs
Summary
PMID 21971825
[Homo sapiens] ZFPM2 inhibits the transcription of hepcidin antimicrobial peptide by suppressing the GATA4 and GATA6 transcription factors.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169946:
The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:40655042-41104592
Strand Forward strand
Band B3.1
Transcripts
ENSMUST00000053467 ENSMUSP00000051335
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001071 nucleic acid binding transcription factor activity
GO:0003677 DNA binding
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001570 vasculogenesis
GO:0001701 in utero embryonic development
GO:0003148 outflow tract septum morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003181 atrioventricular valve morphogenesis
GO:0003192 mitral valve formation
GO:0003195 tricuspid valve formation
GO:0003221 right ventricular cardiac muscle tissue morphogenesis
GO:0006351 transcription, DNA-templated
GO:0007507 heart development
GO:0030324 lung development
GO:0045087 innate immune response (InnateDB)
GO:0045599 negative regulation of fat cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048568 embryonic organ development
GO:0048738 cardiac muscle tissue development
GO:0055008 cardiac muscle tissue morphogenesis
GO:0060412 ventricular septum morphogenesis
GO:0060548 negative regulation of cell death
GO:0060979 vasculogenesis involved in coronary vascular morphogenesis
GO:2000020 positive regulation of male gonad development
GO:2000195 negative regulation of female gonad development
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000169946
View Gene Order
ENSBTAG00000001649
Not yet available
Pathways
NETPATH
REACTOME
REACT_224553
Hemostasis pathway
REACT_198649
Factors involved in megakaryocyte development and platelet production pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8CCH7
TrEMBL A5HE91 Q3UXX7
UniProt Splice Variant
Entrez Gene 22762
UniGene Mm.403186
RefSeq NM_011766 XM_006520897
OMIM
CCDS CCDS27447
HPRD
IMGT
MGI ID MGI:1334444
MGI Symbol Zfpm2
EMBL AF107306 AF118845 AF125166 AK033131 AK135140 BC059241 EF514219
GenPept AAD12182 AAD17251 AAD33250 AAH59241 ABP96991 BAC28166 BAE22436
RNA Seq Atlas 22762

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca