Version 5.4
Mus musculus Protein: Nova1
Summary
InnateDB Protein IDBP-137552.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nova1
Protein Name neuro-oncological ventral antigen 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000021438
InnateDB Gene IDBG-137550 (Nova1)
Protein Structure
UniProt Annotation
Function Functions to regulate alternative splicing in neurons by binding pre-mRNA in a sequence-specific manner to activate exon inclusion. It binds specifically to the sequence UCAUY. Most likely acts to activate the inclusion of exon E3A in the glycine receptor alpha-2 chain and of exon E9 in gamma-aminobutyric-acid receptor gamma-2 subunit via a distal downstream UCAU-rich intronic splicing enhancer. {ECO:0000269PubMed:10719891, ECO:0000269PubMed:12808107, ECO:0000269PubMed:15933722}.
Subcellular Localization Nucleus.
Disease Associations Note=Defects in Nova1 leads to neuronal death in spinal and brainstem neurons.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 164 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 164 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 160 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0051252 regulation of RNA metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID MGI:104297
InterPro IPR004087 K Homology domain
IPR004088 K Homology domain, type 1
PFAM PF00013
PF13014
PRINTS
PIRSF
SMART SM00322
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JKN6
PhosphoSite PhosphoSite-Q9JKN6
TrEMBL A3KMK7
UniProt Splice Variant
Entrez Gene 664883
UniGene Mm.402774
RefSeq NP_067336
MGI ID
MGI Symbol Nova1
OMIM
CCDS CCDS49058
HPRD
IMGT
EMBL AC108802 AC156636 AF232828 AK047565 BC132210 BC132354
GenPept AAF35907 AAI32211 AAI32355 BAC33088

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca