Version 5.4
Mus musculus Protein: Dock11
Summary
InnateDB Protein IDBP-137577.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dock11
Protein Name dedicator of cytokinesis 11
Synonyms 5033414A21Rik; 8030476J24; sph238; Zizimin2;
Species Mus musculus
Ensembl Protein ENSMUSP00000033419
InnateDB Gene IDBG-137575 (Dock11)
Protein Structure
UniProt Annotation
Function Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. {ECO:0000269PubMed:15710388, ECO:0000269PubMed:16968698}.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed in spleen, thymus, bone marrow and peripheral blood lymphocytes. Enriched in B-cells from germinal centers. {ECO:0000269PubMed:15710388}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0017048 Rho GTPase binding
Biological Process
GO:0007264 small GTPase mediated signal transduction
GO:0032319 regulation of Rho GTPase activity
Cellular Component
GO:0005575 cellular_component
Protein Structure and Domains
PDB ID MGI:1923224
InterPro IPR001849 Pleckstrin homology domain
IPR010703 Dedicator of cytokinesis C-terminal
IPR021816 Dedicator of cytokinesis C/D, N-terminal
PFAM PF00169
PF06920
PF11878
PRINTS
PIRSF
SMART SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A2AF47
PhosphoSite PhosphoSite-A2AF47
TrEMBL
UniProt Splice Variant
Entrez Gene 75974
UniGene Mm.32873
RefSeq NP_001009947
MGI ID
MGI Symbol Dock11
OMIM
CCDS CCDS40923
HPRD
IMGT
EMBL AB116935 AL672023 AL672038
GenPept BAD83670 CAM20638 CAM21480

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca