Version 5.4
Mus musculus Protein: Ccdc39
Summary
InnateDB Protein IDBP-137596.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ccdc39
Protein Name coiled-coil domain containing 39
Synonyms 4921507O14Rik; AI447426; AI844750; b2b1304Clo; b2b1735Clo; b2b2025.1Clo; D3Ertd789e;
Species Mus musculus
Ensembl Protein ENSMUSP00000029222
InnateDB Gene IDBG-137594 (Ccdc39)
Protein Structure
UniProt Annotation
Function Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250}. Note=CCDC40 is required for localization to axonemes. {ECO:0000250}.
Disease Associations
Tissue Specificity Strongly expressed in tissues rich in ciliated cells. Expressed in olfactory and vomeronasal sensory neurons and the respiratory epithelium. Expressed in node cells carrying motile cilia, in upper and lower airways, and in ependymal and choroid plexus cells. {ECO:0000269PubMed:21131972}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0001947 heart looping
GO:0030324 lung development
GO:0035469 determination of pancreatic left/right asymmetry
GO:0060285 cilium-dependent cell motility
GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry
GO:0070286 axonemal dynein complex assembly
GO:0071907 determination of digestive tract left/right asymmetry
GO:0071910 determination of liver left/right asymmetry
Cellular Component
GO:0005856 cytoskeleton
GO:0005930 axoneme
Protein Structure and Domains
PDB ID MGI:1289263
InterPro IPR009053 Prefoldin
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D5Y1
PhosphoSite PhosphoSite-Q9D5Y1
TrEMBL
UniProt Splice Variant
Entrez Gene 51938
UniGene Mm.474546
RefSeq NP_080498
MGI ID
MGI Symbol Ccdc39
OMIM
CCDS CCDS17304
HPRD
IMGT
EMBL AK014839 AK030087 BC138917 BC138920 CH466530
GenPept AAI38918 AAI38921 BAB29574 BAC26777 EDL35029

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca