Version 5.4
Mus musculus Protein: Cdc42ep5
Summary
InnateDB Protein IDBP-137608.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdc42ep5
Protein Name CDC42 effector protein (Rho GTPase binding) 5
Synonyms 1700027J19Rik; 2010007O02Rik; Borg3; C85526; CEP5;
Species Mus musculus
Ensembl Protein ENSMUSP00000092508
InnateDB Gene IDBG-137606 (Cdc42ep5)
Protein Structure
UniProt Annotation
Function Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42. {ECO:0000269PubMed:10490598, ECO:0000269PubMed:11035016, ECO:0000269PubMed:11584266}.
Subcellular Localization Endomembrane system {ECO:0000269PubMed:11035016}; Peripheral membrane protein {ECO:0000269PubMed:11035016}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:11035016}.
Disease Associations
Tissue Specificity Highly expressed in the skeletal muscle. {ECO:0000269PubMed:10490598}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017049 GTP-Rho binding
Biological Process
GO:0007254 JNK cascade
GO:0007266 Rho protein signal transduction
GO:0008360 regulation of cell shape
GO:0030838 positive regulation of actin filament polymerization
GO:0031274 positive regulation of pseudopodium assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0012505 endomembrane system
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:1929745
InterPro IPR000095 CRIB domain
PFAM PF00786
PRINTS
PIRSF
SMART SM00285
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Z0X0
PhosphoSite PhosphoSite-Q9Z0X0
TrEMBL D3Z5F0
UniProt Splice Variant
Entrez Gene 58804
UniGene
RefSeq NP_067429
MGI ID
MGI Symbol Cdc42ep5
OMIM
CCDS CCDS20733
HPRD
IMGT
EMBL AC101941 AF102773 AF164119 AK008154 BC006758 BC103774
GenPept AAD17906 AAD48816 AAH06758 AAI03775 BAB25498

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca