Version 5.4
Mus musculus Gene: Cdc42ep5
Summary
InnateDB Gene IDBG-137606.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdc42ep5
Gene Name CDC42 effector protein (Rho GTPase binding) 5
Synonyms 1700027J19Rik; 2010007O02Rik; Borg3; C85526; CEP5
Species Mus musculus
Ensembl Gene ENSMUSG00000063838
Encoded Proteins
IDBP-137608
CDC42 effector protein (Rho GTPase binding) 5
IDBP-537942
CDC42 effector protein (Rho GTPase binding) 5
IDBP-537367
CDC42 effector protein (Rho GTPase binding) 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167617:
CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of, CDC42. The specific function of this protein has not yet been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:4151260-4164860
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000076831 ENSMUSP00000092508
ENSMUST00000143825 ENSMUSP00000117257
ENSMUST00000140410 ENSMUSP00000122849
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017049 GTP-Rho binding
Biological Process
GO:0007254 JNK cascade
GO:0007266 Rho protein signal transduction
GO:0008360 regulation of cell shape
GO:0030838 positive regulation of actin filament polymerization
GO:0031274 positive regulation of pseudopodium assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0012505 endomembrane system
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000167617
View Gene Order
ENSBTAG00000045989
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_021454 XM_006540250
OMIM
CCDS CCDS20733
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca