InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRIM35

Summary

InnateDB Protein

IDBP-13773.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM35

Protein Name

tripartite motif containing 35

Synonyms

HLS5; MAIR;

Species

Homo sapiens

Ensembl Protein

ENSP00000301924

InnateDB Gene

IDBG-13769 (TRIM35)

Protein Structure

UniProt Annotation

Function

May play a role as a tumor suppressor. Implicated in the cell death mechanism (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Found predominantly in cytoplasm with a granular distribution. Found in punctuate nuclear bodies (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0006915	apoptotic process
GO:0008285	negative regulation of cell proliferation
GO:0043065	positive regulation of apoptotic process
GO:0045087	innate immune response
GO:0045930	negative regulation of mitotic cell cycle
GO:1902187	negative regulation of viral release from host cell

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000315 Zinc finger, B-box
IPR001841 Zinc finger, RING-type
IPR001870 B30.2/SPRY domain
IPR003877 SPRY domain
IPR003879 Butyrophylin-like
IPR006574 SPRY-associated
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR018957 Zinc finger, C3HC4 RING-type

PFAM

PF00643
PF13639
PF14634
PF00622
PF13765
PF00097

PRINTS

PR01407

PIRSF

SMART

SM00336
SM00184
SM00449
SM00589

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt