InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fxr1

Summary

InnateDB Protein

IDBP-137737.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fxr1

Protein Name

fragile X mental retardation gene 1, autosomal homolog

Synonyms

1110050J02Rik; 9530073J07Rik; AI851072; Fxr1h; Fxr1p;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000001620

InnateDB Gene

IDBG-137735 (Fxr1)

Protein Structure

UniProt Annotation

Function

RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs. {ECO:0000269PubMed:15128702}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

In early embryogenesis, highest expression in somites and central nervous system. Also expressed in spinal cord, surrounding mesenchymal tissue and undifferentiated gonad. In mid- embryogenesis, most prominent in gonad and muscle tissue. Also expressed in liver, retina, telencephalon and mesencephalon. In late embryogenesis, restricted to skeletal muscle and proliferative active layers of brain. After birth, highly expressed in postmeiotic spermatids. Intermediate levels are found in heart, liver and kidney with lower levels in brain and skeletal muscle. Isoform(s) containing the 27 amino acid pocket (residues 564-590) are present in adult heart and muscle. {ECO:0000269PubMed:10409431, ECO:0000269PubMed:16000371}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002151	G-quadruplex RNA binding
GO:0003723	RNA binding
GO:0003730	mRNA 3'-UTR binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0007517	muscle organ development
GO:0017148	negative regulation of translation
GO:0030154	cell differentiation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005844	polysome
GO:0016020	membrane
GO:0043034	costamere

Protein Structure and Domains

PDB ID

MGI:104860

InterPro

IPR004087 K Homology domain
IPR004088 K Homology domain, type 1
IPR008395 Agenet-like domain
IPR012340 Nucleic acid-binding, OB-fold
IPR022034 Fragile X mental retardation protein family

PFAM

PF00013
PF13014
PF05641
PF12235

PRINTS

PIRSF

SMART

SM00322

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q61584