Version 5.4
Mus musculus Gene: Fxr1
Summary
InnateDB Gene IDBG-137735.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fxr1
Gene Name fragile X mental retardation gene 1, autosomal homolog
Synonyms 1110050J02Rik; 9530073J07Rik; AI851072; Fxr1h; Fxr1p
Species Mus musculus
Ensembl Gene ENSMUSG00000027680
Encoded Proteins
IDBP-137737
fragile X mental retardation gene 1, autosomal homolog
IDBP-621982
fragile X mental retardation gene 1, autosomal homolog
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 19864602
[Homo sapiens] FXR1 is an essential component of a network of nuclear receptors that regulate intestinal innate immunity and homeostasis.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114416:
The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:34020079-34069342
Strand Forward strand
Band A3
Transcripts
ENSMUST00000001620 ENSMUSP00000001620
ENSMUST00000167354 ENSMUSP00000130216
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002151 G-quadruplex RNA binding
GO:0003723 RNA binding
GO:0003730 mRNA 3'-UTR binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0007517 muscle organ development
GO:0017148 negative regulation of translation
GO:0030154 cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005844 polysome
GO:0016020 membrane
GO:0043034 costamere
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000114416
View Gene Order
ENSBTAG00000016457
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu03013
RNA transport pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt Q61584
TrEMBL Q8C7U4
UniProt Splice Variant
Entrez Gene 14359
UniGene
RefSeq NM_001113188 NM_001113189 NM_008053
OMIM
CCDS CCDS50890 CCDS50891
HPRD
IMGT
MGI ID MGI:104860
MGI Symbol Fxr1
EMBL AF124385 AF124386 AF124387 AF124388 AF124389 AF124390 AF124391 AF124392 AF124393 AF124394 AK049231 BC019139 X90875
GenPept AAD30211 AAD30212 AAD30213 AAD30214 AAD30215 AAD30216 AAD30217 AAD30218 AAH19139 BAC33624 CAA62383
RNA Seq Atlas 14359

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca