InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fermt3

Summary

InnateDB Protein

IDBP-137961.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fermt3

Protein Name

fermitin family homolog 3 (Drosophila)

Synonyms

C79673; Kindlin3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000037858

InnateDB Gene

IDBG-137957 (Fermt3)

Protein Structure

UniProt Annotation

Function

Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs). {ECO:0000269PubMed:18278053, ECO:0000269PubMed:18662549, ECO:0000269PubMed:19234461}.

Subcellular Localization

Cell projection, podosome {ECO:0000269PubMed:16876785}. Note=Present in the F-actin surrounding ring structure of podosomes, which are specialized adhesion structures of hematopoietic cells.

Disease Associations

Tissue Specificity

Specifically expressed in hematopoietic cells. {ECO:0000269PubMed:16876785}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005515	protein binding

Biological Process

GO:0007159	leukocyte cell-cell adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0033622	integrin activation
GO:0033632	regulation of cell-cell adhesion mediated by integrin
GO:0034446	substrate adhesion-dependent cell spreading
GO:0070527	platelet aggregation