Version 5.4
Mus musculus Protein: Ptpla
Summary
InnateDB Protein IDBP-137995.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ptpla
Protein Name protein tyrosine phosphatase-like (proline instead of catalytic arginine), member a
Synonyms HACD1;
Species Mus musculus
Ensembl Protein ENSMUSP00000074397
InnateDB Gene IDBG-137993 (Ptpla)
Protein Structure
UniProt Annotation
Function Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis. {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed at high levels in heart, skeletal muscle and testis, weak expression in kidney and liver. {ECO:0000269PubMed:10644438}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0016829 lyase activity
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0007275 multicellular organismal development
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0014902 myotube differentiation
GO:2000045 regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0005575 cellular_component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1353592
InterPro IPR007482 Protein-tyrosine phosphatase-like, PTPLA
PFAM PF04387
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9QY80
PhosphoSite PhosphoSite-Q9QY80
TrEMBL B9EHK9
UniProt Splice Variant
Entrez Gene 30963
UniGene Mm.402978
RefSeq
MGI ID
MGI Symbol Ptpla
OMIM
CCDS CCDS50505
HPRD
IMGT
EMBL AF114493 AK010119 AL844560 BC138116 BC141017 CH466542
GenPept AAF21975 AAI38117 AAI41018 BAB26713 CAM21321 EDL08058

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca