Version 5.4
Mus musculus Gene: Ptpla
Summary
InnateDB Gene IDBG-137993.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ptpla
Gene Name protein tyrosine phosphatase-like (proline instead of catalytic arginine), member a
Synonyms HACD1
Species Mus musculus
Ensembl Gene ENSMUSG00000063275
Encoded Proteins
IDBP-137995
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member a
IDBP-137997
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member a
IDBP-251108
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member a
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165996:
The protein encoded by this gene contains a characteristic catalytic motif of the protein tyrosine phosphatases (PTPs) family. The PTP motif of this protein has the highly conserved arginine residue replaced by a proline residue; thus it may represent a distinct class of PTPs. Members of the PTP family are known to be signaling molecules that regulate a variety of cellular processes. This gene was preferentially expressed in both adult and fetal heart. A much lower expression level was detected in skeletal and smooth muscle tissues, and no expression was observed in other tissues. The tissue specific expression in the developing and adult heart suggests a role in regulating cardiac development and differentiation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:13975563-14056135
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000074854 ENSMUSP00000074397
ENSMUST00000091429 ENSMUSP00000088998
ENSMUST00000114753 ENSMUSP00000110401
ENSMUST00000131730
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0016829 lyase activity
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0007275 multicellular organismal development
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0014902 myotube differentiation
GO:2000045 regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0005575 cellular_component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000165996
View Gene Order
ENSBTAG00000033089
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa01040
Biosynthesis of unsaturated fatty acids pathway
hsa00062
Fatty acid elongation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.241205 Mm.402978
RefSeq NM_001012396 NM_013935
OMIM
CCDS CCDS50504 CCDS50505
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca