Version 5.4
Mus musculus Protein: Coch
Summary
InnateDB Protein IDBP-138040.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Coch
Protein Name coagulation factor C homolog (Limulus polyphemus)
Synonyms AW122937; Coch-5B2; D12H14S564E;
Species Mus musculus
Ensembl Protein ENSMUSP00000082533
InnateDB Gene IDBG-138038 (Coch)
Protein Structure
UniProt Annotation
Function Plays a role in the control of cell shape and motility in the trabecular meshwork. {ECO:0000250}.
Subcellular Localization Secreted, extracellular space {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in inner ear structures.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007605 sensory perception of sound
GO:0008360 regulation of cell shape
GO:0042742 defense response to bacterium
GO:0045087 innate immune response (InnateDB)
GO:0045089 positive regulation of innate immune response
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID MGI:1278313
InterPro IPR002035 von Willebrand factor, type A
IPR004043 LCCL domain
PFAM PF00092
PF03815
PRINTS
PIRSF
SMART SM00327
SM00603
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q62507
PhosphoSite PhosphoSite-Q62507
TrEMBL
UniProt Splice Variant
Entrez Gene 12810
UniGene Mm.416285
RefSeq NP_001185764
MGI ID
MGI Symbol Coch
OMIM
CCDS CCDS25901
HPRD
IMGT
EMBL AF006741 AK028690 AK137336 AK171875 BC045137 Z78163
GenPept AAC39949 AAH45137 BAC26067 BAE23310 BAE42713 CAB01565

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca