Version 5.4
Mus musculus Gene: Coch
Summary
InnateDB Gene IDBG-138038.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Coch
Gene Name coagulation factor C homolog (Limulus polyphemus)
Synonyms AW122937; Coch-5B2; D12H14S564E
Species Mus musculus
Ensembl Gene ENSMUSG00000020953
Encoded Proteins
IDBP-138040
coagulation factor C homolog (Limulus polyphemus)
IDBP-625234
coagulation factor C homolog (Limulus polyphemus)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 23684986
COCH is secreted by follicular dendritic cells to promote antibacterial innate immunity.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100473:
The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated. [provided by RefSeq, Oct 2008]
The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94%% and 79%% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:51593341-51605773
Strand Forward strand
Band B3
Transcripts
ENSMUST00000085412 ENSMUSP00000082533
ENSMUST00000164782 ENSMUSP00000128127
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007605 sensory perception of sound
GO:0008360 regulation of cell shape
GO:0042742 defense response to bacterium
GO:0045087 innate immune response (InnateDB)
GO:0045089 positive regulation of innate immune response
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000100473
View Gene Order
ENSBTAG00000021844
Not yet available
Cross-References
SwissProt Q62507
TrEMBL
UniProt Splice Variant
Entrez Gene 12810
UniGene Mm.21325 Mm.416285
RefSeq NM_001198835 NM_007728 XM_006515454 XM_006515455
OMIM
CCDS CCDS25901
HPRD
IMGT
MGI ID MGI:1278313
MGI Symbol Coch
EMBL AF006741 AK028690 AK137336 AK171875 BC045137 Z78163
GenPept AAC39949 AAH45137 BAC26067 BAE23310 BAE42713 CAB01565
RNA Seq Atlas 12810

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca