InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Smap1

Summary

InnateDB Protein

IDBP-138078.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Smap1

Protein Name

stromal membrane-associated protein 1

Synonyms

1700056O10Rik; 4921514B13Rik; 4921525H11Rik; AI462175;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027339

InnateDB Gene

IDBG-138076 (Smap1)

Protein Structure

UniProt Annotation

Function

GTPase activating protein that acts on ARF6. Plays a role in clathrin-dependent endocytosis. May play a role in erythropoiesis. {ECO:0000269PubMed:15659652, ECO:0000269PubMed:9644265}.

Subcellular Localization

Cell membrane {ECO:0000305PubMed:9644265}; Peripheral membrane protein {ECO:0000305PubMed:9644265}; Cytoplasmic side {ECO:0000305PubMed:9644265}.

Disease Associations

Tissue Specificity

Detected in adult brain, lung, heart, liver, ovary and bone marrow. Detected in stromal cells of the red pulp of adult spleen. {ECO:0000269PubMed:9644265}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008060	ARF GTPase activator activity
GO:0008270	zinc ion binding
GO:0030276	clathrin binding

Biological Process

GO:0032312	regulation of ARF GTPase activity
GO:0043547	positive regulation of GTPase activity
GO:0045648	positive regulation of erythrocyte differentiation
GO:2000369	regulation of clathrin-mediated endocytosis