InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mrc1

Summary

InnateDB Protein

IDBP-138189.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mrc1

Protein Name

mannose receptor, C type 1

Synonyms

AW259686; CD206; MR;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028045

InnateDB Gene

IDBG-138187 (Mrc1)

Protein Structure

UniProt Annotation

Function

Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens. {ECO:0000269PubMed:1421407}.

Subcellular Localization

Endosome membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in macrophages. {ECO:0000269PubMed:1421407}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004888	transmembrane signaling receptor activity
GO:0005537	mannose binding
GO:0030246	carbohydrate binding

Biological Process

GO:0006898	receptor-mediated endocytosis
GO:0007165	signal transduction
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0010008	endosome membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:97142

InterPro

IPR000562 Fibronectin, type II, collagen-binding
IPR000772 Ricin B lectin domain
IPR001304 C-type lectin
IPR002353 Type-2 ice-structuring protein
IPR013806 Kringle-like fold
IPR016187 C-type lectin fold

PFAM

PF00040
PF00652
PF14200
PF00059

PRINTS

PR00356

PIRSF

SMART

SM00059
SM00458
SM00034

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt