InnateDB Protein
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IDBP-138227.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Lrrc16a
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Protein Name
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leucine rich repeat containing 16A
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Synonyms
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1110037D04Rik; AI425970; CARMIL; D130057M20; Lrrc16;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000072662
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InnateDB Gene
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IDBG-138221 (Lrrc16a)
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Protein Structure
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Function |
Binds CAPZA2 with high affinity and significantly decreases CAPZA2 affinity for actin barbed ends. Increases the rate of elongation from seeds in the presence of CAPZA2, however, seems unable to nucleate filaments. Rapidly uncaps barbed ends capped by CAPZA2 and enhances barbed-end actin polymerization. {ECO:0000269PubMed:16054028}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:16054028}. Note=Colocalized with F-actin in lamellipodia but not with F-actin in stress fibers.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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|
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Molecular Function |
Accession |
GO Term |
GO:0032403
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protein complex binding
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1915982
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InterPro |
IPR003590
Leucine-rich repeat, ribonuclease inhibitor subtype
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
SM00368
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TIGRFAMs |
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Modification |
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SwissProt |
Q6EDY6
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PhosphoSite |
PhosphoSite-Q6EDY6
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TrEMBL |
E9Q7X4
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UniProt Splice Variant |
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Entrez Gene |
68732
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UniGene |
Mm.416277
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RefSeq |
NP_081101
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MGI ID |
4K17
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MGI Symbol |
Lrrc16a
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OMIM |
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CCDS |
CCDS36621
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HPRD |
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IMGT |
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EMBL |
AK043591
AK051570
AL590864
AL606464
AL683873
AY437876
BC012229
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GenPept |
AAH12229
AAR96060
BAC31591
BAC34678
CAI35972
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