InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sigmar1

Summary

InnateDB Protein

IDBP-138298.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sigmar1

Protein Name

sigma non-opioid intracellular receptor 1

Synonyms

AL024364; Oprs1; sigma1R;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000071492

InnateDB Gene

IDBG-138294 (Sigmar1)

Protein Structure

UniProt Annotation

Function

Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration. {ECO:0000269PubMed:11149946, ECO:0000269PubMed:14622179, ECO:0000269PubMed:15571673, ECO:0000269PubMed:15777781, ECO:0000269PubMed:9425306, ECO:0000269PubMed:9603192}.

Subcellular Localization

Nucleus inner membrane. Nucleus outer membrane. Endoplasmic reticulum membrane. Lipid droplet. Cell junction. Cell membrane. Cell projection, growth cone. Note=Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum. Enriched at cell-cell communication regions, growth cone and postsynaptic structures. Localization is modulated by ligand- binding.

Disease Associations

Tissue Specificity

Widely expressed with higher expression in liver, brain, kidney and thymus. Expressed throughout the brain with higher expression within cerebral cortex, hippocampus and cerebellum. Within the hippocampus expressed in cornu ammonis pyramidal neurons, the granular cells of the dentate gyrus as well as interneurons. Within the cerebellum, expressed in Purkinje cell bodies. Expressed by neural retina, retinal pigment epithelial cells and lens. {ECO:0000269PubMed:11207432, ECO:0000269PubMed:11476895, ECO:0000269PubMed:11687279, ECO:0000269PubMed:9603192}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004985	opioid receptor activity
GO:0005515	protein binding

Biological Process

GO:0006869	lipid transport
GO:0007399	nervous system development
GO:0038003	opioid receptor signaling pathway
GO:0043523	regulation of neuron apoptotic process

Cellular Component

GO:0005637	nuclear inner membrane
GO:0005640	nuclear outer membrane
GO:0005789	endoplasmic reticulum membrane
GO:0005811	lipid particle
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030426	growth cone