Version 5.4
Mus musculus Gene: Sigmar1
Summary
InnateDB Gene IDBG-138294.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sigmar1
Gene Name sigma non-opioid intracellular receptor 1
Synonyms AL024364; Oprs1; sigma1R
Species Mus musculus
Ensembl Gene ENSMUSG00000036078
Encoded Proteins
IDBP-138296
sigma non-opioid intracellular receptor 1
IDBP-138298
sigma non-opioid intracellular receptor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a transmembrane protein located in the endoplasmic reticulum. The encoded protein is a receptor that binds several endogenous ligands, including N,N-dimethyltryptamine, progesterone and pregnenolone and a variety of of non-opiate compounds. The encoded protein plays a role in regulating the activity of ion channels, acting as a chaperone and protecting cells from oxidative stress. In humans, this receptor has been associated with Alzheimer\'s and Parkinson\'s diseases, stroke and numerous disease conditions such as depression, pain and addiction. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:41738493-41756157
Strand Reverse strand
Band A5
Transcripts
ENSMUST00000059354 ENSMUSP00000056027
ENSMUST00000071561 ENSMUSP00000071492
ENSMUST00000148223
ENSMUST00000133590
ENSMUST00000142840
ENSMUST00000149647
ENSMUST00000146655
ENSMUST00000123524
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0004985 opioid receptor activity
GO:0005515 protein binding
Biological Process
GO:0006869 lipid transport
GO:0007399 nervous system development
GO:0038003 opioid receptor signaling pathway
GO:0043523 regulation of neuron apoptotic process
Cellular Component
GO:0005635 nuclear envelope
GO:0005637 nuclear inner membrane
GO:0005640 nuclear outer membrane
GO:0005789 endoplasmic reticulum membrane
GO:0005811 lipid particle
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030426 growth cone
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000147955
View Gene Order
ENSBTAG00000015804
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.425181
RefSeq NM_001286539 NM_011014
OMIM
CCDS CCDS18070 CCDS71362
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca