InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc25a5

Summary

InnateDB Protein

IDBP-138333.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc25a5

Protein Name

solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5

Synonyms

Ant2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000016463

InnateDB Gene

IDBG-138331 (Slc25a5)

Protein Structure

UniProt Annotation

Function

Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion inner membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 86 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	86 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0007059	chromosome segregation
GO:0008284	positive regulation of cell proliferation
GO:0055085	transmembrane transport
GO:1901029	negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0042645	mitochondrial nucleoid
GO:0070062	extracellular vesicular exosome
GO:0071817	MMXD complex

Protein Structure and Domains

PDB ID

MGI:1353496

InterPro

IPR002067 Mitochondrial carrier protein
IPR002113 Adenine nucleotide translocator 1
IPR018108 Mitochondrial substrate/solute carrier
IPR023395 Mitochondrial carrier domain

PFAM

PF00153

PRINTS

PR00926
PR00927

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P51881