Version 5.4
Mus musculus Protein: Nkrf
Summary
InnateDB Protein IDBP-138505.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nkrf
Protein Name NF-kappaB repressing factor
Synonyms 9430034D17Rik; AW124770; C80287;
Species Mus musculus
Ensembl Protein ENSMUSP00000061546
InnateDB Gene IDBG-138503 (Nkrf)
Protein Structure
UniProt Annotation
Function Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus, nucleolus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
Protein Structure and Domains
PDB ID MGI:1924536
InterPro IPR000467 G-patch domain
IPR001374 Single-stranded nucleic acid binding R3H
PFAM PF01585
PF01424
PRINTS
PIRSF
SMART SM00443
SM00393
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BY02
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 77286
UniGene Mm.21649
RefSeq NP_084167
MGI ID
MGI Symbol Nkrf
OMIM
CCDS CCDS30065
HPRD
IMGT
EMBL AK020455 AK042690 AK079123 AL450399 BC138828 BC138829
GenPept AAI38829 AAI38830 BAB32107 BAC31334 BAC37550 CAM19779

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca