InnateDB Protein
|
IDBP-13857.7
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
RPH3AL
|
Protein Name
|
rabphilin 3A-like (without C2 domains)
|
Synonyms
|
NOC2;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000328977
|
InnateDB Gene
|
IDBG-13853 (RPH3AL)
|
Protein Structure
|
|
Function |
Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells (By similarity). Acts as a potential RAB3B effector protein in epithelial cells. {ECO:0000250, ECO:0000269PubMed:15003533}.
|
Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:15003533}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269PubMed:15003533}. Note=Recruited to the vesicle membrane in a GTP- and RAB3B-dependent manner in epithelial cells.
|
Disease Associations |
|
Tissue Specificity |
Moderate to high levels of expression in thyroid, ovary, stomach, heart, pancreas, skeletal muscle, kidney and liver. Also detected in epithelial cells. {ECO:0000269PubMed:10395805, ECO:0000269PubMed:15003533}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
12
[view]
|
Protein-Protein |
12
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
6 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR010911
Zinc finger, FYVE-type
IPR011011
Zinc finger, FYVE/PHD-type
IPR017455
Zinc finger, FYVE-related
|
PFAM |
PF02318
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9UNE2
|
PhosphoSite |
PhosphoSite-
|
TrEMBL |
I3NI49
|
UniProt Splice Variant |
|
Entrez Gene |
9501
|
UniGene |
Hs.706433
|
RefSeq |
NP_008918
|
HUGO |
HGNC:10296
|
OMIM |
604881
|
CCDS |
CCDS10994
|
HPRD |
05345
|
IMGT |
|
EMBL |
AC108004
AC129507
AF129812
AK000469
BC005153
BC093776
BC113413
CH471108
|
GenPept |
AAD45582
AAH05153
AAH93776
AAI13414
BAA91186
EAW90670
EAW90671
|
|
|