InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RPH3AL

Summary

InnateDB Gene

IDBG-13853.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPH3AL

Gene Name

rabphilin 3A-like (without C2 domains)

Synonyms

NOC2

Species

Homo sapiens

Ensembl Gene

ENSG00000181031

Encoded Proteins

IDBP-13857

rabphilin 3A-like (without C2 domains)

IDBP-13859

rabphilin 3A-like (without C2 domains)

IDBP-599390

rabphilin 3A-like (without C2 domains)

IDBP-759827

IDBP-759958

IDBP-760465

IDBP-761343

IDBP-759098

IDBP-759592

IDBP-763494

IDBP-761855

IDBP-761252

IDBP-760382

IDBP-758575

IDBP-811672

rabphilin 3A-like (without C2 domains)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene plays a direct regulatory role in calcium-ion-dependent exocytosis in both endocrine and exocrine cells and plays a key role in insulin secretion by pancreatic cells. This gene is likely a tumor suppressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:212389-386254

Strand

Reverse strand

Band

p13.3

Transcripts

ENST00000331302	ENSP00000328977
ENST00000323434	ENSP00000319210
ENST00000536489	ENSP00000438224
ENST00000572965
ENST00000572075
ENST00000574722	ENSP00000459716
ENST00000573448	ENSP00000458643
ENST00000575634	ENSP00000461885
ENST00000576420	ENSP00000460080
ENST00000574011
ENST00000573780	ENSP00000459992
ENST00000573588	ENSP00000459975
ENST00000575130	ENSP00000460171
ENST00000577079	ENSP00000459795
ENST00000570638	ENSP00000460580
ENST00000570893
ENST00000574953	ENSP00000459666
ENST00000572866
ENST00000575736	ENSP00000459001
ENST00000576001
ENST00000570954
ENST00000618002	ENSP00000479485

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0017137	Rab GTPase binding
GO:0030274	LIM domain binding
GO:0046872	metal ion binding

Biological Process

GO:0006886	intracellular protein transport
GO:0006887	exocytosis
GO:0017158	regulation of calcium ion-dependent exocytosis
GO:0042493	response to drug
GO:0042593	glucose homeostasis
GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway
GO:0050714	positive regulation of protein secretion

Cellular Component

GO:0005737	cytoplasm
GO:0030141	secretory granule
GO:0030658	transport vesicle membrane
GO:0030667	secretory granule membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000020847

View Gene Order

ENSBTAG00000039819

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.651925 Hs.706433

RefSeq

NM_001190411 NM_001190412 NM_001190413 NM_006987 XM_006721363 XM_006725251

HUGO

OMIM

CCDS

CCDS10994 CCDS54059

HPRD

05345

IMGT

EMBL

GenPept

RNA Seq Atlas