Version 5.4
Homo sapiens Protein: RPH3AL
Summary
InnateDB Protein IDBP-13859.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPH3AL
Protein Name rabphilin 3A-like (without C2 domains)
Synonyms NOC2;
Species Homo sapiens
Ensembl Protein ENSP00000319210
InnateDB Gene IDBG-13853 (RPH3AL)
Protein Structure
UniProt Annotation
Function Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells (By similarity). Acts as a potential RAB3B effector protein in epithelial cells. {ECO:0000250, ECO:0000269PubMed:15003533}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:15003533}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269PubMed:15003533}. Note=Recruited to the vesicle membrane in a GTP- and RAB3B-dependent manner in epithelial cells.
Disease Associations
Tissue Specificity Moderate to high levels of expression in thyroid, ovary, stomach, heart, pancreas, skeletal muscle, kidney and liver. Also detected in epithelial cells. {ECO:0000269PubMed:10395805, ECO:0000269PubMed:15003533}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008092 cytoskeletal protein binding
GO:0017137 Rab GTPase binding
GO:0046872 metal ion binding
Biological Process
GO:0006886 intracellular protein transport
GO:0006887 exocytosis
Cellular Component
GO:0005737 cytoplasm
GO:0030658 transport vesicle membrane
Protein Structure and Domains
PDB ID
InterPro IPR010911 Zinc finger, FYVE-type
IPR011011 Zinc finger, FYVE/PHD-type
PFAM PF02318
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UNE2
PhosphoSite PhosphoSite-
TrEMBL I3NI49
UniProt Splice Variant
Entrez Gene 9501
UniGene Hs.706433
RefSeq NP_001177341
HUGO HGNC:10296
OMIM 604881
CCDS CCDS54059
HPRD 05345
IMGT
EMBL AC108004 AC129507 AF129812 AK000469 BC005153 BC093776 BC113413 CH471108
GenPept AAD45582 AAH05153 AAH93776 AAI13414 BAA91186 EAW90670 EAW90671

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca