Version 5.4
Mus musculus Protein: Suv420h2
Summary
InnateDB Protein IDBP-138838.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Suv420h2
Protein Name suppressor of variegation 4-20 homolog 2 (Drosophila)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000096452
InnateDB Gene IDBG-138836 (Suv420h2)
Protein Structure
UniProt Annotation
Function Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2). {ECO:0000269PubMed:15145825}.
Subcellular Localization Nucleus {ECO:0000269PubMed:15145825}. Chromosome {ECO:0000269PubMed:15145825}. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042799 histone methyltransferase activity (H4-K20 specific)
GO:0070087 chromo shadow domain binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0016571 histone methylation
GO:0034770 histone H4-K20 methylation
GO:0034773 histone H4-K20 trimethylation
Cellular Component
GO:0000780 condensed nuclear chromosome, centromeric region
GO:0005720 nuclear heterochromatin
Protein Structure and Domains
PDB ID MGI:2385262
InterPro IPR001214 SET domain
PFAM PF00856
PRINTS
PIRSF
SMART SM00317
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6Q783
PhosphoSite PhosphoSite-Q6Q783
TrEMBL D3Z2F5
UniProt Splice Variant
Entrez Gene 232811
UniGene Mm.247844
RefSeq NP_001108490
MGI ID 4AU7
MGI Symbol Suv420h2
OMIM
CCDS CCDS20743
HPRD
IMGT
EMBL AC161197 AK154848 AY555193 BC024816 BC085473
GenPept AAH24816 AAH85473 AAT00540 BAE32874

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca