Version 5.4
Mus musculus Gene: Suv420h2
Summary
InnateDB Gene IDBG-138836.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Suv420h2
Gene Name suppressor of variegation 4-20 homolog 2 (Drosophila)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000059851
Encoded Proteins
IDBP-138838
suppressor of variegation 4-20 homolog 2 (Drosophila)
IDBP-264225
suppressor of variegation 4-20 homolog 2 (Drosophila)
IDBP-264227
suppressor of variegation 4-20 homolog 2 (Drosophila)
IDBP-538499
suppressor of variegation 4-20 homolog 2 (Drosophila)
IDBP-542425
suppressor of variegation 4-20 homolog 2 (Drosophila)
IDBP-535649
suppressor of variegation 4-20 homolog 2 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000133247:
SUV420H2 and the related enzyme SUV420H1 (MIM 610881) function as histone methyltransferases that specifically trimethylate nucleosomal histone H4 (see MIM 602822) on lysine-20 (K20) (Schotta et al., 2004 [PubMed 15145825]).[supplied by OMIM, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:4740115-4747514
Strand Forward strand
Band A1
Transcripts
ENSMUST00000098853 ENSMUSP00000096452
ENSMUST00000108583 ENSMUSP00000104224
ENSMUST00000108582 ENSMUSP00000104223
ENSMUST00000135541
ENSMUST00000130215 ENSMUSP00000119323
ENSMUST00000129927
ENSMUST00000160480 ENSMUSP00000124663
ENSMUST00000136177
ENSMUST00000152500
ENSMUST00000130200
ENSMUST00000152431
ENSMUST00000128018 ENSMUSP00000114445
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042799 histone methyltransferase activity (H4-K20 specific)
GO:0070087 chromo shadow domain binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0016571 histone methylation
GO:0034770 histone H4-K20 methylation
GO:0034773 histone H4-K20 trimethylation
Cellular Component
GO:0000780 condensed nuclear chromosome, centromeric region
GO:0005634 nucleus
GO:0005720 nuclear heterochromatin
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000133247
View Gene Order
ENSBTAG00000014087
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00310
Lysine degradation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00310
Lysine degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.247844
RefSeq NM_001115018 NM_146177 XM_006539774
OMIM
CCDS CCDS20743
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca