InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ppif

Summary

InnateDB Protein

IDBP-138879.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppif

Protein Name

peptidylprolyl isomerase F (cyclophilin F)

Synonyms

AW457192; CyP-D; CyP-F; CypD; PPIase;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022419

InnateDB Gene

IDBG-138877 (Ppif)

Protein Structure

UniProt Annotation

Function

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress- induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis. {ECO:0000269PubMed:15800626, ECO:0000269PubMed:15800627, ECO:0000269PubMed:16103352, ECO:0000269PubMed:18684715, ECO:0000269PubMed:19801635, ECO:0000269PubMed:21281446, ECO:0000269PubMed:22726440}.

Subcellular Localization

Mitochondrion matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0005515	protein binding
GO:0016018	cyclosporin A binding
GO:0042277	peptide binding

Biological Process

GO:0000413	protein peptidyl-prolyl isomerization
GO:0002931	response to ischemia
GO:0006457	protein folding
GO:0006979	response to oxidative stress
GO:0008637	apoptotic mitochondrial changes
GO:0010849	regulation of proton-transporting ATPase activity, rotational mechanism
GO:0010939	regulation of necrotic cell death
GO:0010940	positive regulation of necrotic cell death
GO:0032780	negative regulation of ATPase activity
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0046902	regulation of mitochondrial membrane permeability
GO:0070266	necroptotic process
GO:0070301	cellular response to hydrogen peroxide
GO:0071243	cellular response to arsenic-containing substance
GO:0071277	cellular response to calcium ion
GO:0090200	positive regulation of release of cytochrome c from mitochondria
GO:0090201	negative regulation of release of cytochrome c from mitochondria
GO:0090324	negative regulation of oxidative phosphorylation
GO:1902445	regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
GO:2000276	negative regulation of oxidative phosphorylation uncoupler activity
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005753	mitochondrial proton-transporting ATP synthase complex
GO:0005757	mitochondrial permeability transition pore complex
GO:0005759	mitochondrial matrix