Version 5.4
Mus musculus Gene: Ppif
Summary
InnateDB Gene IDBG-138877.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppif
Gene Name peptidylprolyl isomerase F (cyclophilin F)
Synonyms AW457192; CyP-D; CyP-F; CypD; PPIase
Species Mus musculus
Ensembl Gene ENSMUSG00000021868
Encoded Proteins
IDBP-138879
peptidylprolyl isomerase F (cyclophilin F)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108179:
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is part of the mitochondrial permeability transition pore in the inner mitochondrial membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:25694154-25700468
Strand Forward strand
Band A3
Transcripts
ENSMUST00000022419 ENSMUSP00000022419
ENSMUST00000125881
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005515 protein binding
GO:0016018 cyclosporin A binding
GO:0042277 peptide binding
Biological Process
GO:0000413 protein peptidyl-prolyl isomerization
GO:0002931 response to ischemia
GO:0006457 protein folding
GO:0006979 response to oxidative stress
GO:0008637 apoptotic mitochondrial changes
GO:0010849 regulation of proton-transporting ATPase activity, rotational mechanism
GO:0010939 regulation of necrotic cell death
GO:0010940 positive regulation of necrotic cell death
GO:0032780 negative regulation of ATPase activity
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0046902 regulation of mitochondrial membrane permeability
GO:0070266 necroptotic process
GO:0070301 cellular response to hydrogen peroxide
GO:0071243 cellular response to arsenic-containing substance
GO:0071277 cellular response to calcium ion
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:0090324 negative regulation of oxidative phosphorylation
GO:1902445 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
GO:2000276 negative regulation of oxidative phosphorylation uncoupler activity
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005753 mitochondrial proton-transporting ATP synthase complex
GO:0005757 mitochondrial permeability transition pore complex
GO:0005759 mitochondrial matrix
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000108179
View Gene Order
ENSBTAG00000016711
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04020
Calcium signaling pathway pathway
mmu05012
Parkinson's disease pathway
mmu05016
Huntington's disease pathway
mmu05145
Toxoplasmosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04020
Calcium signaling pathway pathway
hsa05012
Parkinson's disease pathway
hsa05016
Huntington's disease pathway
hsa05145
Toxoplasmosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.41656
RefSeq NM_134084 XM_006518390
OMIM
CCDS CCDS26874
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca