InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBE2D4

Summary

InnateDB Protein

IDBP-13917.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2D4

Protein Name

ubiquitin-conjugating enzyme E2D 4 (putative)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000222402

InnateDB Gene

IDBG-13915 (UBE2D4)

Protein Structure

UniProt Annotation

Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11' and 'Lys-48'-linked polyubiquitination. {ECO:0000269PubMed:20061386}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 89 experimentally validated interaction(s) in this database.

Experimentally validated
Total	89 [view]
Protein-Protein	89 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016881	acid-amino acid ligase activity

Biological Process

GO:0035519	protein K29-linked ubiquitination
GO:0044314	protein K27-linked ubiquitination
GO:0070534	protein K63-linked ubiquitination
GO:0070936	protein K48-linked ubiquitination
GO:0070979	protein K11-linked ubiquitination
GO:0085020	protein K6-linked ubiquitination