InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atp7b

Summary

InnateDB Protein

IDBP-139463.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp7b

Protein Name

ATPase, Cu++ transporting, beta polypeptide

Synonyms

Atp7a; tx; WND;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000006742

InnateDB Gene

IDBG-139461 (Atp7b)

Protein Structure

UniProt Annotation

Function

Involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile. {ECO:0000250}.

Subcellular Localization

Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Predominantly found in the trans-Golgi network (TGN). Not redistributed to the plasma membrane in response to elevated copper levels (By similarity). {ECO:0000250}.

Disease Associations

Note=Defects in Atp7b are the cause of the toxic milk mouse mutant (tx) phenotype, characterized by accumulation of copper in the liver in a manner similar to that observed in patients with Wilson disease.

Tissue Specificity

Detected in liver and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004008	copper-exporting ATPase activity
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019829	cation-transporting ATPase activity
GO:0043682	copper-transporting ATPase activity
GO:0046872	metal ion binding

Biological Process

GO:0006812	cation transport
GO:0006825	copper ion transport
GO:0006878	cellular copper ion homeostasis
GO:0006882	cellular zinc ion homeostasis
GO:0007595	lactation
GO:0008152	metabolic process
GO:0015677	copper ion import
GO:0015680	intracellular copper ion transport
GO:0030001	metal ion transport
GO:0046688	response to copper ion
GO:0051208	sequestering of calcium ion
GO:0060003	copper ion export

Cellular Component

GO:0005770	late endosome
GO:0005802	trans-Golgi network
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0016323	basolateral plasma membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:103297

InterPro

IPR001757 Cation-transporting P-type ATPase
IPR006121 Heavy metal-associated domain, HMA
IPR006122 Heavy metal-associated domain, copper ion-binding
IPR008250 P-type ATPase, A domain
IPR023214 HAD-like domain
IPR027256 Cation-transporting P-type ATPase, subfamily IB

PFAM

PF00403
PF00122
PF00702
PF08282
PF13419

PRINTS

PR00119
PR00120
PR00941

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q64446