InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Atp7b

Summary

InnateDB Gene

IDBG-139461.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp7b

Gene Name

ATPase, Cu++ transporting, beta polypeptide

Synonyms

Atp7a; tx; WND

Species

Mus musculus

Ensembl Gene

ENSMUSG00000006567

Encoded Proteins

IDBP-139463

ATPase, Cu++ transporting, beta polypeptide

IDBP-259626

ATPase, Cu++ transporting, beta polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123191:
This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:21992785-22060305

Strand

Reverse strand

Band

Transcripts

ENSMUST00000006742	ENSMUSP00000006742
ENSMUST00000110738	ENSMUSP00000106366

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004008	copper-exporting ATPase activity
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019829	cation-transporting ATPase activity
GO:0043682	copper-transporting ATPase activity
GO:0046872	metal ion binding

Biological Process

GO:0006812	cation transport
GO:0006825	copper ion transport
GO:0006878	cellular copper ion homeostasis
GO:0006882	cellular zinc ion homeostasis
GO:0007595	lactation
GO:0008152	metabolic process
GO:0015677	copper ion import
GO:0015680	intracellular copper ion transport
GO:0030001	metal ion transport
GO:0035434	copper ion transmembrane transport
GO:0046688	response to copper ion
GO:0051208	sequestering of calcium ion
GO:0060003	copper ion export

Cellular Component

GO:0005770	late endosome
GO:0005802	trans-Golgi network
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0016323	basolateral plasma membrane
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000123191

View Gene Order

ENSBTAG00000010353

Not yet available

Pathways

NETPATH

REACTOME

REACT_262350

Ion channel transport pathway

REACT_253400

Transmembrane transport of small molecules pathway

REACT_250224

Ion transport by P-type ATPases pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_25149

Ion transport by P-type ATPases pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_25300

Ion channel transport pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.290842 Mm.460838 Mm.87854

RefSeq

NM_007511 XM_006509007

OMIM

CCDS

CCDS22168

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas