InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Keap1

Summary

InnateDB Protein

IDBP-139533.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Keap1

Protein Name

kelch-like ECH-associated protein 1

Synonyms

INRF2; mKIAA0132;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000062467

InnateDB Gene

IDBG-139531 (Keap1)

Protein Structure

UniProt Annotation

Function

Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15379550}. Nucleus {ECO:0000269PubMed:15379550}. Note=Shuttles between cytoplasm and nucleus. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 72 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	72 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0010499	proteasomal ubiquitin-independent protein catabolic process
GO:0016567	protein ubiquitination
GO:0045087	innate immune response (InnateDB)
GO:0045604	regulation of epidermal cell differentiation
GO:0071353	cellular response to interleukin-4

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005813	centrosome
GO:0030496	midbody
GO:0031463	Cul3-RING ubiquitin ligase complex

Protein Structure and Domains

PDB ID

MGI:1858732

InterPro

IPR000210 BTB/POZ-like
IPR006652 Kelch repeat type 1
IPR011333 BTB/POZ fold
IPR011498 Kelch repeat type 2
IPR011705 BTB/Kelch-associated
IPR013069 BTB/POZ
IPR017096 Kelch-like protein, gigaxonin type

PFAM

PF01344
PF07646
PF07707
PF00651

PRINTS

PIRSF

PIRSF037037

SMART

SM00225
SM00612
SM00875

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt