Version 5.4
Mus musculus Gene: Keap1
Summary
InnateDB Gene IDBG-139531.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Keap1
Gene Name kelch-like ECH-associated protein 1
Synonyms INRF2; mKIAA0132
Species Mus musculus
Ensembl Gene ENSMUSG00000003308
Encoded Proteins
IDBP-139533
kelch-like ECH-associated protein 1
IDBP-620492
kelch-like ECH-associated protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 24011591
Phosphorylation of Sqstm1 (p62) activates the Keap1-Nrf2 pathway during selective autophagy
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000079999:
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:21229730-21239332
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000049567 ENSMUSP00000062467
ENSMUST00000164812 ENSMUSP00000131029
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 72 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 72 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0010499 proteasomal ubiquitin-independent protein catabolic process
GO:0016567 protein ubiquitination
GO:0045087 innate immune response (InnateDB)
GO:0045604 regulation of epidermal cell differentiation
GO:0071353 cellular response to interleukin-4
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0030496 midbody
GO:0031463 Cul3-RING ubiquitin ligase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000079999
View Gene Order
ENSBTAG00000003543
Not yet available
Pathways
NETPATH
REACTOME
REACT_236645
Class I MHC mediated antigen processing & presentation pathway
REACT_230745
Immune System pathway
REACT_199115
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_229531
Adaptive Immune System pathway
KEGG
mmu04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Cross-References
SwissProt Q9Z2X8
TrEMBL Q05DM3 Q3UWI4
UniProt Splice Variant
Entrez Gene 50868
UniGene Mm.248266
RefSeq NM_016679 NM_001110305 NM_001110306 NM_001110307
OMIM
CCDS CCDS22897
HPRD
IMGT
MGI ID MGI:1858732
MGI Symbol Keap1
EMBL AB020063 AF454353 AK046178 AK076234 AK129061 AK136319 AK150437 AK150485 AK152142 AK154430 AK155507 AK159858 BC006729 BC055732
GenPept AAH06729 AAH55732 AAL84711 BAA34639 BAC32621 BAC36267 BAC97871 BAE22931 BAE29559 BAE29601 BAE30980 BAE32581 BAE33299 BAE35433
RNA Seq Atlas 50868

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca