Version 5.4
Mus musculus Protein: Akap7
Summary
InnateDB Protein IDBP-139552.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Akap7
Protein Name A kinase (PRKA) anchor protein 7
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000097590
InnateDB Gene IDBG-139548 (Akap7)
Protein Structure
UniProt Annotation
Function Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium (By similarity). {ECO:0000250}.
Subcellular Localization Lateral cell membrane {ECO:0000250}; Lipid- anchor {ECO:0000269PubMed:9545239}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0051018 protein kinase A binding
Biological Process
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0008104 protein localization
GO:0008150 biological_process
Cellular Component
GO:0005634 nucleus
GO:0016328 lateral plasma membrane
Protein Structure and Domains
PDB ID MGI:1859150
InterPro IPR019511 Protein kinase A anchor protein, RI-RII subunit-binding domain
PFAM PF10470
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O55074
PhosphoSite PhosphoSite-O55074
TrEMBL Q8BVR3
UniProt Splice Variant
Entrez Gene 432442
UniGene Mm.487103
RefSeq XP_006512849
MGI ID
MGI Symbol Akap7
OMIM
CCDS
HPRD
IMGT
EMBL AC153549 AC153550 AF047716 AK076839 CH466540
GenPept AAC40085 BAC36503 EDL04795

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca