InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Akap7

Summary

InnateDB Protein

IDBP-139554.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Akap7

Protein Name

A kinase (PRKA) anchor protein 7

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043624

InnateDB Gene

IDBG-139548 (Akap7)

Protein Structure

UniProt Annotation

Function

Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane- associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium (By similarity). {ECO:0000250UniProtKB:Q9P0M2, ECO:0000305}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12804576}. Cytoplasm {ECO:0000269PubMed:12804576}. Note=In oocytes, localizes to the nucleus, to germinal vesicles and throughout the cytoplasm. {ECO:0000269PubMed:12804576}.

Disease Associations

Tissue Specificity

Expressed in oocytes. {ECO:0000269PubMed:12804576}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0034237	protein kinase A regulatory subunit binding
GO:0051018	protein kinase A binding

Biological Process

GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0008104	protein localization
GO:0008152	metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:1859150

InterPro

IPR009097 RNA ligase/cyclic nucleotide phosphodiesterase
IPR019510 Protein kinase A anchor protein, nuclear localisation signal domain
IPR019511 Protein kinase A anchor protein, RI-RII subunit-binding domain

PFAM

PF10469
PF10470

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q7TN79

PhosphoSite