InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: USP7

Summary

InnateDB Protein

IDBP-13962.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

USP7

Protein Name

ubiquitin specific peptidase 7 (herpes virus-associated)

Synonyms

HAUSP; TEF1;

Species

Homo sapiens

Ensembl Protein

ENSP00000371310

InnateDB Gene

IDBG-13958 (USP7)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 275 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	275 [view]
Protein-Protein	273 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0004197	cysteine-type endopeptidase activity
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008134	transcription factor binding
GO:0008234	cysteine-type peptidase activity
GO:0031625	ubiquitin protein ligase binding
GO:0036459	ubiquitinyl hydrolase activity

Biological Process

GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007275	multicellular organismal development
GO:0010216	maintenance of DNA methylation
GO:0016032	viral process
GO:0016579	protein deubiquitination
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0045087	innate immune response (InnateDB)
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0016605	PML body

Protein Structure and Domains

PDB ID

InterPro

IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR002083 MATH
IPR008974 TRAF-like
IPR024729 ICP0-binding domain of Ubiquitin-specific protease 7
IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain

PFAM

PF00443
PF00917
PF12436

PRINTS

PIRSF

SMART

SM00061

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q93009