InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: USP7

Summary

InnateDB Gene

IDBG-13958.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

USP7

Gene Name

ubiquitin specific peptidase 7 (herpes virus-associated)

Synonyms

HAUSP; TEF1

Species

Homo sapiens

Ensembl Gene

ENSG00000187555

Encoded Proteins

IDBP-13960

ubiquitin specific peptidase 7 (herpes virus-associated)

IDBP-13962

ubiquitin specific peptidase 7 (herpes virus-associated)

IDBP-590054

ubiquitin specific peptidase 7 (herpes virus-associated)

IDBP-753768

IDBP-753922

IDBP-750256

IDBP-753743

IDBP-753316

IDBP-751857

IDBP-751891

IDBP-753071

IDBP-747289

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 18952891

Cytoplasmic USP7 binds to and deubiquitinates TRAF6 and IKBKG, thus terminating TLR-mediated NF-kappaB and JNK activation

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:8892094-8964514

Strand

Reverse strand

Band

p13.2

Transcripts

ENST00000344836	ENSP00000343535
ENST00000381886	ENSP00000371310
ENST00000542333	ENSP00000439272
ENST00000570256
ENST00000563085	ENSP00000454795
ENST00000569230	ENSP00000457237
ENST00000565883
ENST00000562615
ENST00000566004	ENSP00000456150
ENST00000567329
ENST00000563043	ENSP00000459594
ENST00000566224
ENST00000569448
ENST00000567113
ENST00000566273	ENSP00000455719
ENST00000566131
ENST00000567692	ENSP00000458027
ENST00000565455	ENSP00000456258
ENST00000564117	ENSP00000457815
ENST00000562051
ENST00000563961	ENSP00000454362

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 275 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	275 [view]
Protein-Protein	273 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0004197	cysteine-type endopeptidase activity
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008134	transcription factor binding
GO:0008234	cysteine-type peptidase activity
GO:0031625	ubiquitin protein ligase binding
GO:0036459	ubiquitinyl hydrolase activity

Biological Process

GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007275	multicellular organismal development
GO:0010216	maintenance of DNA methylation
GO:0016032	viral process
GO:0016579	protein deubiquitination
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0045087	innate immune response (InnateDB)
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016605	PML body

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022710

View Gene Order

ENSBTAG00000005455

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

foxopathway

FoxO family signaling

p53regulationpathway

p53 pathway

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.606360 Hs.706130 Hs.743739

RefSeq

NM_001286457 NM_001286458 NM_003470

HUGO

OMIM

CCDS

CCDS32385 CCDS66941

HPRD

03950

IMGT

EMBL

GenPept

RNA Seq Atlas