InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Smpd4

Summary

InnateDB Protein

IDBP-139722.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Smpd4

Protein Name

sphingomyelin phosphodiesterase 4

Synonyms

4122402O22Rik; mKIAA1418;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000087620

InnateDB Gene

IDBG-139720 (Smpd4)

Protein Structure

UniProt Annotation

Function

Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane {ECO:0000250}; Single- pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004767	sphingomyelin phosphodiesterase activity
GO:0046872	metal ion binding
GO:0050290	sphingomyelin phosphodiesterase D activity

Biological Process

GO:0006685	sphingomyelin catabolic process
GO:0046475	glycerophospholipid catabolic process
GO:0046513	ceramide biosynthetic process
GO:0071356	cellular response to tumor necrosis factor

Cellular Component

GO:0000139	Golgi membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0005802	trans-Golgi network
GO:0016021	integral component of membrane