Version 5.4
Mus musculus Gene: Smpd4
Summary
InnateDB Gene IDBG-139720.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Smpd4
Gene Name sphingomyelin phosphodiesterase 4
Synonyms 4122402O22Rik; mKIAA1418
Species Mus musculus
Ensembl Gene ENSMUSG00000005899
Encoded Proteins
IDBP-139722
sphingomyelin phosphodiesterase 4
IDBP-139724
sphingomyelin phosphodiesterase 4
IDBP-625510
sphingomyelin phosphodiesterase 4
IDBP-625514
sphingomyelin phosphodiesterase 4
IDBP-625515
sphingomyelin phosphodiesterase 4
IDBP-625516
sphingomyelin phosphodiesterase 4
IDBP-625520
sphingomyelin phosphodiesterase 4
IDBP-625527
sphingomyelin phosphodiesterase 4
IDBP-625530
sphingomyelin phosphodiesterase 4
IDBP-625531
sphingomyelin phosphodiesterase 4
IDBP-625532
sphingomyelin phosphodiesterase 4
IDBP-625534
sphingomyelin phosphodiesterase 4
IDBP-625535
sphingomyelin phosphodiesterase 4
IDBP-625537
sphingomyelin phosphodiesterase 4
IDBP-625538
sphingomyelin phosphodiesterase 4
IDBP-625539
sphingomyelin phosphodiesterase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136699:
Sphingomyelinases (EC 3.1.4.12), such as SMPD4, catalyze the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide (Krut et al., 2006 [PubMed 16517606]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:17619354-17644828
Strand Forward strand
Band A3
Transcripts
ENSMUST00000090159 ENSMUSP00000087620
ENSMUST00000006053 ENSMUSP00000006053
ENSMUST00000087486
ENSMUST00000171435 ENSMUSP00000131560
ENSMUST00000167362
ENSMUST00000163476 ENSMUSP00000131867
ENSMUST00000168101 ENSMUSP00000129995
ENSMUST00000165363 ENSMUSP00000130720
ENSMUST00000166322
ENSMUST00000169662 ENSMUSP00000125819
ENSMUST00000170401
ENSMUST00000167217 ENSMUSP00000130570
ENSMUST00000172182 ENSMUSP00000126093
ENSMUST00000166091
ENSMUST00000163592 ENSMUSP00000126998
ENSMUST00000165092 ENSMUSP00000133249
ENSMUST00000170996 ENSMUSP00000129074
ENSMUST00000170117 ENSMUSP00000132279
ENSMUST00000170366 ENSMUSP00000130990
ENSMUST00000163997 ENSMUSP00000128595
ENSMUST00000170273 ENSMUSP00000129957
ENSMUST00000164292
ENSMUST00000167592
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004767 sphingomyelin phosphodiesterase activity
GO:0046872 metal ion binding
GO:0050290 sphingomyelin phosphodiesterase D activity
Biological Process
GO:0006685 sphingomyelin catabolic process
GO:0008152 metabolic process
GO:0046475 glycerophospholipid catabolic process
GO:0046513 ceramide biosynthetic process
GO:0071356 cellular response to tumor necrosis factor
Cellular Component
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000136699
View Gene Order
ENSBTAG00000002130
Not yet available
Pathways
NETPATH
REACTOME
REACT_199008
Glycosphingolipid metabolism pathway
REACT_188937
Metabolism pathway
REACT_245163
Sphingolipid metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
KEGG
mmu00600
Sphingolipid metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_116105
Glycosphingolipid metabolism pathway
REACT_19323
Sphingolipid metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00600
Sphingolipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.34659 Mm.412346
RefSeq NM_001164609 NM_001164610 NM_001164611 NM_029945 XM_006522720 XM_006522721 XM_006522722 XM_006522724 XM_006522729
OMIM
CCDS CCDS28009 CCDS49779 CCDS49780 CCDS49781
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca