InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: U2af2

Summary

InnateDB Protein

IDBP-139853.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

U2af2

Protein Name

U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2

Synonyms

65kDa;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000005041

InnateDB Gene

IDBG-139851 (U2af2)

Protein Structure

UniProt Annotation

Function

Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 123 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	123 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0044822	poly(A) RNA binding
GO:0070742	C2H2 zinc finger domain binding