InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tbp

Summary

InnateDB Protein

IDBP-139923.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tbp

Protein Name

TATA box binding protein

Synonyms

Gtf2d; GTF2D1; SCA17; TFIID;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000014911

InnateDB Gene

IDBG-139921 (Tbp)

Protein Structure

UniProt Annotation

Function

General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre- initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:16412700}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 146 interaction(s) predicted by orthology.

Experimentally validated
Total	54 [view]
Protein-Protein	46 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	146 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0006352	DNA-templated transcription, initiation
GO:0006366	transcription from RNA polymerase II promoter
GO:0006383	transcription from RNA polymerase III promoter
GO:0007283	spermatogenesis
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0000120	RNA polymerase I transcription factor complex
GO:0001939	female pronucleus
GO:0001940	male pronucleus
GO:0005634	nucleus
GO:0005669	transcription factor TFIID complex
GO:0005672	transcription factor TFIIA complex
GO:0005719	nuclear euchromatin
GO:0005737	cytoplasm
GO:0045120	pronucleus