Version 5.4
Mus musculus Gene: Tbp
Summary
InnateDB Gene IDBG-139921.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tbp
Gene Name TATA box binding protein
Synonyms Gtf2d; GTF2D1; SCA17; TFIID
Species Mus musculus
Ensembl Gene ENSMUSG00000014767
Encoded Proteins
IDBP-139923
TATA box binding protein
IDBP-401669
TATA box binding protein
IDBP-401668
TATA box binding protein
IDBP-401666
TATA box binding protein
IDBP-537141
TATA box binding protein
IDBP-535322
TATA box binding protein
IDBP-539562
TATA box binding protein
IDBP-541975
TATA box binding protein
IDBP-536785
TATA box binding protein
IDBP-535903
TATA box binding protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112592:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 32-39, and expansion of the number of repeats increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:15499888-15528379
Strand Forward strand
Band A2
Transcripts
ENSMUST00000014911 ENSMUSP00000014911
ENSMUST00000119879 ENSMUSP00000114007
ENSMUST00000118001 ENSMUSP00000113999
ENSMUST00000117593 ENSMUSP00000112794
ENSMUST00000159197 ENSMUSP00000125691
ENSMUST00000162505 ENSMUSP00000124317
ENSMUST00000147081 ENSMUSP00000120484
ENSMUST00000143924 ENSMUSP00000122696
ENSMUST00000155051 ENSMUSP00000117551
ENSMUST00000153480 ENSMUSP00000114471
ENSMUST00000149518
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 146 interaction(s) predicted by orthology.
Experimentally validated
Total 54 [view]
Protein-Protein 46 [view]
Protein-DNA 8 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 146 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001103 RNA polymerase II repressing transcription factor binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0044212 transcription regulatory region DNA binding
GO:0070491 repressing transcription factor binding
Biological Process
GO:0006352 DNA-templated transcription, initiation
GO:0006366 transcription from RNA polymerase II promoter
GO:0006383 transcription from RNA polymerase III promoter
GO:0007283 spermatogenesis
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0000120 RNA polymerase I transcription factor complex
GO:0001939 female pronucleus
GO:0001940 male pronucleus
GO:0005634 nucleus
GO:0005669 transcription factor TFIID complex
GO:0005672 transcription factor TFIIA complex
GO:0005719 nuclear euchromatin
GO:0005737 cytoplasm
GO:0045120 pronucleus
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000112592
View Gene Order
Pathways
NETPATH
REACTOME
REACT_230204
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
REACT_245058
RNA Polymerase I Transcription pathway
REACT_244415
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_233104
RNA Polymerase III Transcription Initiation pathway
REACT_244380
RNA Polymerase II Transcription Initiation pathway
REACT_255334
RNA Polymerase II Promoter Escape pathway
REACT_250309
RNA Polymerase III Transcription Initiation From Type 1 Promoter pathway
REACT_257165
RNA Polymerase I Transcription Termination pathway
REACT_232708
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
REACT_251592
RNA Polymerase III Transcription Initiation From Type 2 Promoter pathway
REACT_261233
RNA Polymerase III Abortive And Retractive Initiation pathway
REACT_205737
Epigenetic regulation of gene expression pathway
REACT_224328
SIRT1 negatively regulates rRNA Expression pathway
REACT_255009
RNA Polymerase II Pre-transcription Events pathway
REACT_233572
Gene Expression pathway
REACT_207809
Negative epigenetic regulation of rRNA expression pathway
REACT_232235
RNA Polymerase I Promoter Escape pathway
REACT_240511
RNA Polymerase I Promoter Clearance pathway
REACT_259097
RNA Polymerase I Chain Elongation pathway
REACT_242255
RNA Polymerase II Transcription pathway
REACT_237241
RNA Polymerase III Transcription pathway
REACT_240508
RNA Polymerase III Transcription Initiation From Type 3 Promoter pathway
REACT_235780
RNA Polymerase I Transcription Initiation pathway
KEGG
mmu03022
Basal transcription factors pathway
mmu05016
Huntington's disease pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_22339
RNA Polymerase III Abortive And Retractive Initiation pathway
REACT_571
RNA Polymerase III Transcription Initiation From Type 3 Promoter pathway
REACT_1036
RNA Polymerase III Transcription Initiation From Type 2 Promoter pathway
REACT_347
RNA Polymerase III Transcription Initiation From Type 1 Promoter pathway
REACT_1074
RNA Polymerase I Transcription Termination pathway
REACT_2204
RNA Polymerase I Chain Elongation pathway
REACT_1913
RNA Polymerase I Promoter Escape pathway
REACT_953
RNA Polymerase I Transcription Initiation pathway
REACT_1655
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
REACT_22107
RNA Polymerase II Pre-transcription Events pathway
REACT_2089
RNA Polymerase II Promoter Escape pathway
REACT_1851
RNA Polymerase II Transcription Initiation pathway
REACT_834
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
REACT_6332
HIV Transcription Initiation pathway
REACT_6253
RNA Polymerase II HIV Promoter Escape pathway
REACT_6233
Transcription of the HIV genome pathway
REACT_6361
Late Phase of HIV Life Cycle pathway
REACT_1309
RNA Polymerase I Transcription pathway
REACT_281
RNA Polymerase III Transcription Initiation pathway
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_1974
RNA Polymerase I Promoter Clearance pathway
REACT_200856
NoRC negatively regulates rRNA expression pathway
REACT_200827
SIRT1 negatively regulates rRNA Expression pathway
REACT_1366
RNA Polymerase II Transcription pathway
REACT_6256
HIV Life Cycle pathway
REACT_1371
RNA Polymerase III Transcription pathway
REACT_6185
HIV Infection pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_200834
Negative epigenetic regulation of rRNA expression pathway
KEGG
hsa03022
Basal transcription factors pathway
hsa05016
Huntington's disease pathway
INOH
PID NCI
rb_1pathway
Regulation of retinoblastoma protein
myc_represspathway
Validated targets of C-MYC transcriptional repression
reg_gr_pathway
Glucocorticoid receptor regulatory network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.244820 Mm.414004 Mm.489273
RefSeq NM_013684
OMIM
CCDS CCDS37454
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca