Version 5.4
Homo sapiens Protein: VPS53
Summary
InnateDB Protein IDBP-13998.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VPS53
Protein Name vacuolar protein sorting 53 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000291074
InnateDB Gene IDBG-13990 (VPS53)
Protein Structure
UniProt Annotation
Function May be involved in retrograde transport of early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. {ECO:0000269PubMed:15878329, ECO:0000269PubMed:18367545}.
Subcellular Localization Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
Cellular Component
GO:0000938 GARP complex
GO:0010008 endosome membrane
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR007234 Vps53-like, N-terminal
IPR010989 t-SNARE
PFAM PF04100
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5VIR6
PhosphoSite PhosphoSite-Q5VIR6
TrEMBL
UniProt Splice Variant
Entrez Gene 55275
UniGene Hs.691997
RefSeq NP_060759
HUGO HGNC:25608
OMIM 615850
CCDS CCDS10995
HPRD 07720
IMGT
EMBL AC015853 AC027455 AF246287 AF318335 AK001841 AK290343 AY444797 BC006116 CH471108 EU021218
GenPept AAH06116 AAK27973 AAL55842 AAS20944 ABW03005 BAA91935 BAF83032 EAW90661

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca