InnateDB Protein
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IDBP-140042.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Lamp2
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Protein Name
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lysosomal-associated membrane protein 2
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Synonyms
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CD107b; Lamp II; Lamp-2; Lamp-2a; Lamp-2b; Lamp-2c; LGP-B; Mac3;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000016678
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InnateDB Gene
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IDBG-140038 (Lamp2)
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Protein Structure
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Function |
Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.
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Subcellular Localization |
Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
33 [view]
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|
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Molecular Function |
Accession |
GO Term |
GO:0019904
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protein domain specific binding
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:96748
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InterPro |
IPR002000
Lysosome-associated membrane glycoprotein
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PFAM |
PF01299
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PRINTS |
PR00336
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P17047
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PhosphoSite |
PhosphoSite-P17047
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
16784
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UniGene |
Mm.418582
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RefSeq |
NP_001017959
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MGI ID |
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MGI Symbol |
Lamp2
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OMIM |
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CCDS |
CCDS30092
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HPRD |
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IMGT |
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EMBL |
AK032974
AK159272
AK163933
AL513356
BC138718
BC138723
CH466570
J05287
M32017
M32018
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GenPept |
AAA39412
AAA39429
AAA39430
AAI38719
AAI38724
BAC28106
BAE34951
BAE37543
CAM17143
CAM17144
EDL29016
EDL29018
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