InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lamp2

Summary

InnateDB Protein

IDBP-140044.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lamp2

Protein Name

lysosomal-associated membrane protein 2

Synonyms

CD107b; Lamp II; Lamp-2; Lamp-2a; Lamp-2b; Lamp-2c; LGP-B; Mac3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000052283

InnateDB Gene

IDBG-140038 (Lamp2)

Protein Structure

UniProt Annotation

Function

Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding

Biological Process

GO:0050821

protein stabilization

Cellular Component

GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005770	late endosome
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030670	phagocytic vesicle membrane
GO:0031088	platelet dense granule membrane
GO:0031902	late endosome membrane
GO:0070062	extracellular vesicular exosome