Version 5.4
Mus musculus Protein: Lgsn
Summary
InnateDB Protein IDBP-140175.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lgsn
Protein Name lengsin, lens protein with glutamine synthetase domain
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000059871
InnateDB Gene IDBG-140173 (Lgsn)
Protein Structure
UniProt Annotation
Function May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity. {ECO:0000269PubMed:18178558}.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed in lens. {ECO:0000269PubMed:18178558}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004356 glutamate-ammonia ligase activity
GO:0005515 protein binding
Biological Process
GO:0006542 glutamine biosynthetic process
GO:0006807 nitrogen compound metabolic process
Cellular Component
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID MGI:2672844
InterPro IPR008146 Glutamine synthetase, catalytic domain
IPR008147 Glutamine synthetase, beta-Grasp
PFAM PF00120
PF03951
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CIX8
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 266744
UniGene Mm.389093
RefSeq NP_705829
MGI ID 2J9I
MGI Symbol Lgsn
OMIM
CCDS CCDS14859
HPRD
IMGT
EMBL AF545851 BC117745 BC117746 BC128067
GenPept AAI17746 AAI17747 AAI28068 AAN38298

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca